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Frontline Health Care Workers in Scotland and Their Families Are at Increased Risk of Hospitalization from COVID

These researchers identified 158,445 Scottish health care workers between 18 and 65 years of age who were employed by the National Health Service. They used Scottish employment databases to create linkages to other health-related databases and to identify members of their households (n = 229,905). Additionally, the researchers used these same databases to identify people [...]

Frontline Health Care Workers in Scotland and Their Families Are at Increased Risk of Hospitalization from COVID2020-11-21T11:44:52-05:00

Convalescent Plasma Does Not Reduce Worsening nor All-Cause Mortality in Patients Hospitalized with Moderate COVID in India (PLACID Trial)

n this open-label phase II trial from 39 hospitals in India, the researchers randomized patients to standard care (n = 229) or standard care plus convalescent plasma (n = 235). The patients had all been hospitalized with moderate illness (PaO2/FiO2 ratio between 200 mm Hg and 300 mm Hg or a respiratory rate of more [...]

Convalescent Plasma Does Not Reduce Worsening nor All-Cause Mortality in Patients Hospitalized with Moderate COVID in India (PLACID Trial)2020-11-08T07:21:47-05:00

Hives and Itchy Skin at Night : 5 Ways to Ease the Itch and Sleep Better

HIVES OVERVIEW "Urticaria" or hives are raised areas of the skin that itch intensely and are red with a pale center. Hives develop when there is a reaction that activates immune cells in the skin called mast cells and release natural chemicals mainly histamine, which causes hive. In most cases, hives appear suddenly and disappear [...]

Hives and Itchy Skin at Night : 5 Ways to Ease the Itch and Sleep Better2020-11-01T06:29:55-05:00

Antibodies Persist for Four Months after Infection; Infection Fatality Ratio 0.3%, Much Higher in Older Patients.

This Icelandic study measured a variety of IgG and IgM antibodies to SARS-CoV-2 in six groups of Icelanders who had either never been tested or had tested negative and in two groups of Icelanders who had tested positive and had recovered. They weighted the sample by age and sex to estimate the number of Icelanders [...]

Antibodies Persist for Four Months after Infection; Infection Fatality Ratio 0.3%, Much Higher in Older Patients.2020-10-05T07:53:28-04:00

Meta-analysis of Seven RCTs Confirms That Systemic Corticosteroids Reduce 28-Day COVID-19 Mortality

The World Health Organization has created a Rapid Evidence Appraisal for COVID-19 Therapies (REACT) working group to perform an ongoing series of meta-analyses. This meta-analysis did a careful search of clinical trial registries to identify all ongoing or completed studies comparing a systemic corticosteroid with placebo or usual care in patients who were critically ill [...]

Meta-analysis of Seven RCTs Confirms That Systemic Corticosteroids Reduce 28-Day COVID-19 Mortality2020-09-21T05:06:31-04:00

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19

Abstract Introduction: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. Methods: Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients between February 24, 2020, and May 13, 2020. Results: Of 878 patients in the analysis, 83 (9.5%) received famotidine. In comparison to patients not treated with famotidine, patients treated with [...]

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-192020-08-29T12:02:38-04:00

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses

Abstract Objectives: As schools plan for re-opening, understanding the potential role children play in the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive severe illness in children is critical. Study design: Children ages 0-22 years with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting to urgent care clinics or being [...]

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses2020-08-22T12:46:01-04:00

Identification of SARS-CoV-2 RNA in Healthcare Heating, Ventilation, and Air Conditioning Units

Available information on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission by small particle aerosols continues to evolve rapidly. To assess the potential role of heating, ventilation, and air conditioning (HVAC) systems in airborne viral transmission, this study sought to determine the viral presence, if any, on air handling units in a healthcare setting where [...]

Identification of SARS-CoV-2 RNA in Healthcare Heating, Ventilation, and Air Conditioning Units2020-08-16T09:13:13-04:00

Physical distancing interventions shows moderate reduction of incidence of coronavirus disease 2019 with caveats: natural experiment in 149

Objective : To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. Design : Natural experiment using interrupted time series analysis, with results synthesised using meta-analysis. Setting : 149 countries or regions, with data on daily reported cases of covid-19 from the European Centre for Disease Prevention and Control [...]

Physical distancing interventions shows moderate reduction of incidence of coronavirus disease 2019 with caveats: natural experiment in 1492020-08-08T12:08:24-04:00

Use of N95, Surgical, and Cloth Masks to Prevent COVID-19 in Health Care and Community Settings: Living Practice Points From the American College of Physicians

Regardless of the use of respiratory PPE, other procedures to reduce the transmission of SARS-CoV-2 infection should be followed, including maintaining physical distance, self-isolation, quarantine, frequent hand hygiene (using soap and water or alcohol-based hand rub), covering coughs and sneezes by using a bent elbow or paper tissue, refraining from touching the face, and frequent [...]

Use of N95, Surgical, and Cloth Masks to Prevent COVID-19 in Health Care and Community Settings: Living Practice Points From the American College of Physicians2020-08-01T12:55:12-04:00