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Meta-analysis of Seven RCTs Confirms That Systemic Corticosteroids Reduce 28-Day COVID-19 Mortality

The World Health Organization has created a Rapid Evidence Appraisal for COVID-19 Therapies (REACT) working group to perform an ongoing series of meta-analyses. This meta-analysis did a careful search of clinical trial registries to identify all ongoing or completed studies comparing a systemic corticosteroid with placebo or usual care in patients who were critically ill [...]

Meta-analysis of Seven RCTs Confirms That Systemic Corticosteroids Reduce 28-Day COVID-19 Mortality2020-09-21T05:06:31-04:00

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19

Abstract Introduction: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. Methods: Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients between February 24, 2020, and May 13, 2020. Results: Of 878 patients in the analysis, 83 (9.5%) received famotidine. In comparison to patients not treated with famotidine, patients treated with [...]

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-192020-08-29T12:02:38-04:00

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses

Abstract Objectives: As schools plan for re-opening, understanding the potential role children play in the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive severe illness in children is critical. Study design: Children ages 0-22 years with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting to urgent care clinics or being [...]

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses2020-08-22T12:46:01-04:00

Identification of SARS-CoV-2 RNA in Healthcare Heating, Ventilation, and Air Conditioning Units

Available information on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission by small particle aerosols continues to evolve rapidly. To assess the potential role of heating, ventilation, and air conditioning (HVAC) systems in airborne viral transmission, this study sought to determine the viral presence, if any, on air handling units in a healthcare setting where [...]

Identification of SARS-CoV-2 RNA in Healthcare Heating, Ventilation, and Air Conditioning Units2020-08-16T09:13:13-04:00

Physical distancing interventions shows moderate reduction of incidence of coronavirus disease 2019 with caveats: natural experiment in 149

Objective : To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. Design : Natural experiment using interrupted time series analysis, with results synthesised using meta-analysis. Setting : 149 countries or regions, with data on daily reported cases of covid-19 from the European Centre for Disease Prevention and Control [...]

Physical distancing interventions shows moderate reduction of incidence of coronavirus disease 2019 with caveats: natural experiment in 1492020-08-08T12:08:24-04:00

Use of N95, Surgical, and Cloth Masks to Prevent COVID-19 in Health Care and Community Settings: Living Practice Points From the American College of Physicians

Regardless of the use of respiratory PPE, other procedures to reduce the transmission of SARS-CoV-2 infection should be followed, including maintaining physical distance, self-isolation, quarantine, frequent hand hygiene (using soap and water or alcohol-based hand rub), covering coughs and sneezes by using a bent elbow or paper tissue, refraining from touching the face, and frequent [...]

Use of N95, Surgical, and Cloth Masks to Prevent COVID-19 in Health Care and Community Settings: Living Practice Points From the American College of Physicians2020-08-01T12:55:12-04:00

Promising Early Data from New COVID-19 Vaccine Studies Showing Safety and potential Efficacy

Around the world, more than 100 candidate vaccines against SARS-CoV-2 are in various stages of development and testing. On May 18, US biotech firm Moderna revealed the first data from a human trial: its COVID-19 vaccine triggered an immune response in people, and protected mice from lung infections with the coronavirus SARS-CoV-2. The current study [...]

Promising Early Data from New COVID-19 Vaccine Studies Showing Safety and potential Efficacy2020-07-25T13:33:05-04:00

Hydroxychloroquine and Azithromycin use in COVID-19 :Final chapter is not written yet

Over the last few months several studies has shown conflicting efficacy and safety of Hydroxychloroquine (HCQ) alone or in association with azithromycin or Doxycycline. Most recent data now published in International Journal of Infectious Diseases showing mortality benefit of HCQ alone or in association with Azithromycin in the treatment of COVID-19. In this observational study [...]

Hydroxychloroquine and Azithromycin use in COVID-19 :Final chapter is not written yet2020-07-18T12:14:08-04:00

Yale Treatment Algorithm for Hospitalized ADULTS with Non – Severe* COVID-19

Yale Ad-Hoc COVID-19 Treatment Team algorithms and protocols - multiple algorithms are assembled into a series of color-coded guidance sheets for hospitalist and internist to use. This algorithm is last updated on 4/27/20 and as such still include Hydroxychloroquine in treatment pathway, which is not a standard of care currently. However, rest of the treatment [...]

Yale Treatment Algorithm for Hospitalized ADULTS with Non – Severe* COVID-192020-07-11T23:44:12-04:00

How to protect yourself against COVID-19

COVID-19 is an infectious disease caused by a new coronavirus introduced to humans for the first time. It is spread from person to person mainly through the droplets produced when an infected person speaks, coughs or sneezes. Watch this short animation to learn more about COVID-19 and how to protect yourself against it. [...]

How to protect yourself against COVID-192020-03-10T07:12:10-04:00