Latest in Pulmonary News

Latest in Pulmonary News2019-02-15T07:28:32-05:00

Study: Mysterious vaping lung injuries may have flown under regulatory radar

It was the arrival of the second man in his early 20s gasping for air that alarmed Dixie Harris, MD. Young patients rarely get so sick, so fast, with a severe lung illness, and this was her second case in a matter of days.

Then she saw three more patients at her Utah telehealth clinic with similar symptoms. They did not have infections, but all had been vaping. When Dr. Harris heard several teenagers in Wisconsin had been hospitalized in similar cases, she quickly alerted her state health department.

As patients in hospitals across the country combat a mysterious illness linked to e-cigarettes, federal and state investigators are frantically trying to trace the outbreaks to specific vaping products that, until recently, were virtually unregulated.

As of Aug. 22, 2019, 193 potential vaping-related illnesses in 22 states had been reported to the Centers for Disease Control and Prevention. Wisconsin, which first put out an alert in July, has at least 16 confirmed and 15 suspected cases. Illinois has reported 34 patients, 1 of whom has died. Indiana is investigating 24 cases.

Lung doctors said they had seen warning signs for years that vaping could be hazardous as they treated patients. Medically it seemed problematic since it often involved inhaling chemicals not normally inhaled into the lungs. Despite that, assessing the safety of a new product storming the market fell between regulatory cracks, leaving doctors unsure where to register concerns before the outbreak. The Food and Drug Administration took years to regulate e-cigarettes once a court determined it had the authority to do so.

“You don’t know what you’re putting into your lungs when you vape,” said Dr. Harris, a critical care pulmonologist. “It’s purported to be safe, but how do you know if it’s safe? To me, it’s a very dangerous thing.”

Off the radar

When e-cigarettes came to market about a decade ago, they fell into a regulatory no man’s land. They are not a food, not a drug, and not a medical device, any of which would have put them immediately in the FDA’s purview. And, until a few years ago, they weren’t even lumped in with tobacco products.

As a result, billions of dollars of vaping products have been sold online, at big-box retailers, and in corner stores without going through the FDA’s rigorous review process to assess their safety. Companies like Juul, Blu, and NJoy quickly established their brands of devices and cartridges, or pods. And thousands of related products are sold, sometimes on the black market, over the Internet, or beyond.

“It makes it really tough because we don’t know what we’re looking for,” said Ruth Lynfield, MD, the state epidemiologist for Minnesota, where several patients were admitted to the ICU as a result of the illness. She added that, if it turns out that the products in question were sold by unregistered retailers and manufacturers “on the street,” outbreak sleuths will have a harder time figuring out exactly what is in them.

With e-cigarettes, people can vape – or smoke – nicotine products, selecting flavorings like mint, mango, blueberry crème brûlée, or cookies and milk. They can also inhale cannabis products. Many are hopeful that e-cigarettes might be useful smoking cessation tools, but some research has called that into question.

The mysterious pulmonary disease cases have been linked to vaping, but it’s unclear whether there is a common device or chemical. In some states, including California and Utah, all of the patients had vaped cannabis products. One or more substances could be involved, health officials have said. The products used by several victims are being tested to see what they contained.

Because e-cigarettes aren’t classified as drugs or medical devices, which have well-established FDA databases to track adverse events, doctors say there has been no clear way to report and track health problems related to vaping products.

And this has apparently been the case for years.

Multiple doctors described seeing earlier cases of severe lung problems linked to vaping that were not officially reported or included in the current CDC count.

Laura Crotty Alexander, MD, a pulmonologist and researcher with the University of California, San Diego, said she saw her first case about 2 years ago. A young man had been vaping for months with the same device but developed acute lung injury when he switched flavors. She strongly suspected a link, but did not report the illness anywhere.

“It wasn’t that I didn’t want to report it, it’s that there’s no pathway” to do so, Dr. Alexander said.

She said she’s concerned that many physicians haven’t been asking patients about e-cigarette use and that there’s no way to document a case like this in the medical coding system.

John E. Parker, MD, of West Virginia University, Morgantown, said he saw his first patient with pneumonia tied to vaping in 2015. Doctors there were intrigued enough to report on the case at the annual meeting of the American College of Chest Physicians. Dr. Parker and his team didn’t contact a federal agency, and Dr. Parker said it was unclear whom to call.

Numerous other cases have been reported in medical journals and at professional conferences in the years since. The FDA’s voluntary system for reporting tobacco-related health problems included 96 seizures and only 1 lung ailment tied to e-cigarettes between April and June 2019. The system appears to be utilized most by concerned citizens, rather than manufacturers or health care professionals.

But several lung specialists said that due to the patchwork nature of regulatory oversight over the years, the true scope of the problem is yet to be identified.

“We do know that e-cigarettes do not emit a harmless aerosol,” said Brian King, PhD, MPH, a deputy director in the Office on Smoking and Health at the CDC in a call with media on Aug. 23 about the outbreak. “It is possible that some of these cases were already occurring but we were not picking them up.”

Source: https://www.mdedge.com/chestphysician/article/207168/pulmonology/mysterious-vaping-lung-injuries-may-have-flown-under

The Caveat to Inhaled Corticosteroids for Asthma

For the past several years, the trend has been to use inhaled corticosteroid(ICS) early and often for patients with asthma. And now the 2019 Global Initiative for Asthma (GINA) guidelines recommend using ICS as first-line therapy (step 1) as needed).[1] This change is sure to increase ICS use even more.
The logic behind using ICS early and often is sound, but when it comes to asthma, nothing is simple. The first problem is that asthma is overdiagnosed (some estimates put the rate as high as 30%-35%).[2] Even when the diagnosis is correct, up to 50% of patients with the disease will have a noneosinophilic, non-type 2 phenotype that is less likely to respond to ICS.[3] Both scenarios leave physicians chasing symptoms with higher and higher doses of ICS.

So what?” you might say. ICS is safe, and there is minimal systemic absorption. Better to ensure that all asthmatics have ICS on board and risk overtreating than to withhold therapy from someone who needs it. The problem is, ICS is not risk-free. Furthermore, the risk-benefit skews further toward adverse effects, even in those who benefit from treatment, as the dose is increased. A recent review estimates that over 90% of efficacy is achieved at the “lowest” ICS dose As the dose is increased, the incremental benefit is minimal, while side effects increase in a linear fashion.

Patients with mild disease are particularly problematic. They make up the majority (50%-75%) diagnosed with asthma, and they are the group most likely to be affected by the changes to step 1 in the GINA guidelines. A recent study found high rates of noneosinophilic asthma in this group and response to ICS that wasn’t better than to placebo.

The “early and often” approach to ICS is fine. It should come with an important caveat, though. If your patient isn’t responding and you find yourself escalating ICS dose for persistent symptoms, make sure you have the right diagnosis. Once you’ve confirmed you do, take a look at the patient’s serum eosinophil count and ensure that you have the right asthma phenotype. If in doubt, find a good pulmonologist to refer the patient to.

Author : Aaron B. Holley, MD
Source : https://www.medscape.com/viewarticle/915649

Obstructive sleep apnea: focus on myofunctional therapy

PURPOSE:

Orofacial myofunctional therapy (OMT) is a modality of treatment for children and adults with obstructive sleep apnea (OSA) to promote changes in the musculature of the upper airways. This review summarizes and discusses the effects of OMT on OSA, the therapeutic programs employed, and their possible mechanisms of action.

METHODS:

We conducted an online literature search using the databases MEDLINE/PubMed, EMBASE, and Web of Science. Search terms were “obstructive sleep apnea” in combination with “myofunctional therapy” OR “oropharyngeal exercises” OR “speech therapy”. We considered original articles in English and Portuguese containing a diagnosis of OSA based on polysomnography (PSG). The primary outcomes of interest for this review were objective measurement derived from PSG and subjective sleep symptoms. The secondary outcome was the evaluation of orofacial myofunctional status.

RESULTS:

Eleven studies were included in this review. The studies reviewed reveal that several benefits of OMT were demonstrated in adults, which include significant decrease of apnea-hypopnea index (AHI), reduced arousal index, improvement in subjective symptoms of daytime sleepiness, sleep quality, and life quality. In children with residual apnea, OMT promoted a decrease of AHI, increase in oxygen saturation, and improvement of orofacial myofunctional status. Few of the studies reviewed reported the effects of OMT on the musculature.

CONCLUSION:

The present review showed that OMT is effective for the treatment of adults in reducing the severity of OSA and snoring, and improving the quality of life. OMT is also successful for the treatment of children with residual apnea. In addition, OMT favors the adherence to continuous positive airway pressure. However, randomized and high-quality studies are still rare, and the effects of treatment should also be analyzed on a long-term basis, including measures showing if changes occurred in the musculature.

Author: de Felício CM, da Silva Dias FV, Trawitzki LVV

Source: https://www.ncbi.nlm.nih.gov/pubmed/30233265

Obstructive sleep apnea: Who should be tested, and how?

Patients who have risk factors for obstructive sleep apnea (OSA) or who report symptoms of OSA should be screened for it, first with a complete sleep history and standardized questionnaire, and then by objective testing if indicated. The gold standard test for OSA is polysomnography performed overnight in a sleep laboratory. Home testing is an option in certain instances.

Common risk factors include obesity, resistant hypertension, retrognathia, large neck circumference (> 17 inches in men, > 16 inches in women), and history of stroke, atrial fibrillation, nocturnal arrhythmias, heart failure, and pulmonary hypertension. Screening is also recommended for any patient who is found on physical examination to have upper-airway narrowing or who reports symptoms such as loud snoring, observed episodes of apnea, gasping or choking at night, unrefreshing sleep, morning headaches, unexplained fatigue, and excessive tiredness during the day.

The American Academy of Sleep Medicine suggests three opportunities to screen for OSA1:

  • At routine health maintenance visits
  • If the patient reports clinical symptoms of OSA
  • If the patient has risk factors.

A DISMAL STATISTIC

The prevalence of OSA in the United States is high, estimated to be 2% in women and 4% in men in the middle-aged work force,2 and even more in blacks, Asians, and older adults.3 Yet only 10% of people with OSA are diagnosed4—a dismal statistic considering the association of OSA with resistant hypertension5 and with a greater risk of stroke,6cardiovascular disease, and death.7

CONSEQUENCES OF UNTREATED OSA

Untreated OSA is associated with a number of conditions7:

  • Hypertension. OSA is one of the most common conditions associated with resistant hypertension. Patients with severe OSA and resistant hypertension who comply with continuous positive airway pressure (CPAP) treatment have significant reductions in blood pressure.
  • Coronary artery disease. OSA is twice as common in people with coronary artery disease as in those with no coronary artery disease. In patients with coronary artery disease and OSA, CPAP may reduce the rate of nonfatal and fatal cardiovascular events.
  • Heart failure. OSA is common in patients with systolic dysfunction (11% to 37%). OSA also has been detected in more than 50% of patients with heart failure with preserved systolic function. CPAP treatment can improve ejection fraction in patients with systolic dysfunction.
  • Arrythmias. Atrial fibrillation, nonsustained ventricular tachycardia, and complex ventricular ectopy have been reported to be significantly more common in people with OSA.8 If the underlying cardiac conduction system is normal and there is no significant thyroid dysfunction, bradyarrhythmias and heart block may be treated effectively with CPAP.7 Treatment of OSA may decrease the incidence and severity of ventricular arrhythmias.7
  • Sudden cardiac death. OSA was independently associated with sudden cardiac death in a longitudinal study.9
  • Stroke. The Sleep Heart Health Study6 showed that OSA is 30% more common in patients who developed ischemic stroke. Long-term CPAP treatment in moderate to severe OSA and ischemic stroke is associated with a reduction in the mortality rate.10
  • Diabetes. The Sleep Heart Health Study showed that OSA is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus.11

A QUESTIONNAIRE HELPS IDENTIFY WHO NEEDS TESTING

If you suspect OSA, consider administering a sleep disorder questionnaire such as the Berlin,12 the Epworth Sleepiness Scale, or the STOP-Bang questionnaire (Table 1). The STOP-Bang questionnaire is an easy-to-use tool that expands on the STOP questionnaire (snoring, tiredness, observed apnea, high blood pressure) with the addition of body mass index, age, neck size, and gender. The Berlin questionnaire has been validated in the primary care setting.12 The STOP-Bang questionnaire has been validated in preoperative settings13 but not in the primary care setting (although it has been commonly used in primary care).

WHICH TEST TO ORDER?

If the score on the questionnaire indicates a moderate or high risk of OSA, the patient should undergo objective testing with polysomnography or, in certain instances, home testing.1Polysomnography is the gold standard. Home testing costs less and is easier to arrange, but the American Academy of Sleep Medicine recommends it as an alternative to polysomnography, in conjunction with a comprehensive sleep evaluation, only in the following situations14:

  • If the patient has a high pretest probability of moderate to severe OSA
  • If immobility or critical illness makes polysomnography unfeasible
  • If direct monitoring of the response to non-CPAP treatments for sleep apnea is needed.

Home testing for OSA should not be used in the following situations:

  • If the patient has significant morbidity such as moderate to severe pulmonary disease, neuromuscular disease, or congestive heart failure
  • In evaluating a patient suspected of having comorbid sleep disorders such as central sleep apnea, periodic limb movement disorder, insomnia, parasomnias, circadian rhythm disorder, or narcolepsy
  • In screening of asymptomatic patients.

Home testing has important drawbacks. It may underestimate the severity of sleep apnea. The rate of false-negative results may be as high as 17%. If the home test was thought to be technically inadequate or the results were inconsistent with those that were expected—ie, if the patient has a high pretest probability of OSA based on risk factors or symptoms but negative results on home testing—then the patient should undergo polysomnography.14

DIAGNOSIS

The diagnosis of OSA is confirmed if the number of apnea events per hour (ie, the apnea-hypopnea index) on polysomnography or home testing is more than 15, regardless of symptoms, or more than 5 in a patient who reports OSA symptoms. An apnea-hypopnea index of 5 to 14 indicates mild OSA, 15 to 30 indicates moderate OSA, and greater than 30 indicates severe OSA.

BENEFITS OF TREATMENT

Treatment of OSA with CPAP reduces the 10-year risk of fatal and nonfatal motor vehicle accidents by 52%, the 10-year expected number of myocardial infarctions by 49%, and the 10-year risk of stroke by 31%.7 It has also been found to be cost-effective, for men and women of all ages with moderate to severe OSA.15

Lies, Damned Lies, and Asthma

Aminophylline suppositories, cocaine nasal packs, and potassium iodide were commonly prescribed for asthma in 1963 when Claude A. Frazier, MD, wrote a thoughtful essay on the do’s and don’ts in treating allergic asthma in Consultant.1 How times have changed! Dr Frazier left us with several clinical observations that are prophetic. He was correct in asserting in his introduction that “allergic asthma is a problem disease; its capricious nature defies control and keeps the health of the asthmatic always in a precarious state. And, improper treatment can make the asthma worse.” His wisdom preceded the proliferation of consensus guidelines, beginning with the National Institutes of Health National Asthma Education and Prevention Program (NIH-NAEPP) Expert Panel Report (EPR-1) in 1991.2 Here I offer an updated list of do’s and don’ts and a perspective from one clinician’s experience with difficult-to-control asthma since 1998 ……

Samuel Louie, MD
Professor of Medicine, Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine; and Director, UC Davis Asthma Network (UCAN) at UC Davis Health, Sacramento, California

Citation:
Louie S. Lies, damned lies, and asthma. Consultant. 2018;58(12):336-342.

Source: https://www.consultant360.com/article/pulmonology/asthma/lies-damned-lies-and-asthma

What exercises can help increase lung capacity?

The lungs are responsible for the exchange of oxygen and carbon dioxide that keep the brain, heart, and other parts of the body healthy. Age, smoking, inhaling pollutants, and other factors can affect lung function.
People cannot necessarily change their lung capacity in terms of how much oxygen their lungs can hold. However, they can perform exercises that may reduce shortness of breath when they have a lower lung function than is desirable. An example could be someone who has chronic obstructive pulmonary disease (COPD).

A person should always talk to their doctor before starting any exercise program, including breathing exercises. This is especially true if they have an underlying condition such as COPD.

Pursed lip breathing

Pursed lip breathing is an exercise that can help to keep the airways open for longer to help air flow. The exercise is easy to perform, and people can do it almost anywhere. To do pursed lip breathing:

  • Sit up straight. Practicing good posture can help promote better lung movement.
  • Breathe in deeply through your nose in a slow, controlled fashion.
  • Purse your lips, which is much like making a “kissing” face where your lips are almost, but not quite, touching.
  • Breathe out through your pursed lips, making a goal of breathing out twice as long as breathing in. Some people may find it beneficial to set a timer, such as focusing on breathing in for 5 seconds and exhaling for 10 seconds.

This exercise can be helpful for someone who is not as physically active as some others and may not be using their breathing muscles as frequently. Those with COPD can also benefit from performing this exercise.

Belly breathing

Belly breathing is an exercise that focuses on targeting and strengthening the diaphragm muscle that allows a person to take a deep breath. People can follow these steps to accomplish this exercise:

  • Rest your hand or another lightweight object on your stomach.
  • Breathe in slowly through your nose to note how your stomach rises and falls when breathing.
  • Breathe out through your mouth.
  • Breathe in through your nose again, this time trying to get your stomach to go up more than it did with the previous breath.
  • Try to exhale for a much longer time than when you inhale, such as two to three times as long.
  • Periodically, roll your shoulders forward and backward and move your head side to side to ensure you are not building tension in your upper body.

This exercise from the American Lung Association helps to improve the rate at which the lungs fill and empty air. A person can practice belly breathing and pursed lip breathing for about 5 to 10 minutes every day to enhance their lung function.

Interval training

For people who have problems with breathlessness and shortness of breath while exercising, interval training may be a better solution than steady-state exercise. Interval training involves alternating a more challenging exercise with a slower recovery period. Examples include walking at a very fast pace for 1 minute, then walking more slowly for 2 minutes. Similarly, a person may perform a weightlifting activity for 1 minute, such as bicep curls or lunges, then step to the side or walk at a gentle pace for 2 to 3 minutes. Interval training allows the lungs time to recover before challenging them again. Whenever a person is exercising and becomes short of breath, slowing down for a few minutes and performing pursed lip breathing can help. They can continue pursed lip breathing until feelings of breathlessness subside.

Tips for preserving lung health

While lung exercises cannot reverse damage already done to the lungs, they can help a person use their lungs to their best capacity. Exercises are not the only thing a person can do to improve or protect their lung health. Other steps people can take include:

  • refraining from smoking
  • drinking plenty of water
  • staying physically active

If a person has symptoms of poor lung health, such as shortness of breath during daily activities, pain when breathing, or a cough that will not go away, they should see their doctor. The earlier lung problems receive a diagnosis and treatment, the better the treatment outcome is likely to be.

Takeaway

Lung exercises can be beneficial to lung function. Pursed lip breathing and diaphragm breathing are two common focuses for people in pulmonary rehabilitation to improve their lung function.
Before starting any exercise program, including a lung exercise one, it is best to talk to a doctor to ensure there are not any restrictions or individual recommendations for best results.

Author : By Rachel Nall, RN, MSN
Source : https://www.medicalnewstoday.com/articles/323787.php

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  1. Yang, T, Wang, C, Li, S, Guo, XF, Li, D. Dietary intakes of fruits and vegetables and lung cancer risk in participants with different smoking status: a meta-analysis of prospective cohort studies. Asia Pac J Clin Nutr. 2019;28 (4):770-782. doi: 10.6133/apjcn.201912_28(4).0014. PubMed PMID:31826375 .
  2. Qi, X, Qi, C, Wu, T, Qin, B, Hu, Y. Early intervention with supplemental parenteral nutrition reduces the incidence of granulocytopenia-related infections in patients with lung cancer: a retrospective cohort study. Asia Pac J Clin Nutr. 2019;28 (4):711-719. doi: 10.6133/apjcn.201912_28(4).0006. PubMed PMID:31826367 .
  3. Butler, CC, Gillespie, D, Francis, NA. C-Reactive Protein for Antibiotic Use in COPD Exacerbations. Reply. N. Engl. J. Med. 2019;381 (24):2372. doi: 10.1056/NEJMc1912624. PubMed PMID:31826349 .
  4. Yildiz, H. C-Reactive Protein for Antibiotic Use in COPD Exacerbations. N. Engl. J. Med. 2019;381 (24):2371-2372. doi: 10.1056/NEJMc1912624. PubMed PMID:31826348 .
  5. Verbakel, JY, Van den Bruel, A, Thompson, M. C-Reactive Protein for Antibiotic Use in COPD Exacerbations. N. Engl. J. Med. 2019;381 (24):2371. doi: 10.1056/NEJMc1912624. PubMed PMID:31826347 .
  6. Glinz, D. C-Reactive Protein for Antibiotic Use in COPD Exacerbations. N. Engl. J. Med. 2019;381 (24):2371. doi: 10.1056/NEJMc1912624. PubMed PMID:31826346 .
  7. Brunetti, G, Belisario, DC, Bortolotti, S, Storlino, G, Colaianni, G, Faienza, MF et al.. LIGHT/TNFSF14 promotes osteolytic bone metastases in non-small cell lung cancer patients. J. Bone Miner. Res. 2019; :. doi: 10.1002/jbmr.3942. PubMed PMID:31826304 .
  8. Chen, LW, Lyons, B, Navarro, P, Shivappa, N, Mehegan, J, Murrin, CM et al.. Maternal dietary inflammatory potential and quality are associated with offspring asthma risk over 10-year follow-up: the Lifeways Cross-Generation Cohort Study. Am. J. Clin. Nutr. 2019; :. doi: 10.1093/ajcn/nqz297. PubMed PMID:31826246 .
  9. Menezes, RAM, Pavanitto, DR, Nascimento, LFC. Spatial distribution of hospitalization rates of children due to pneumonia in the Unified Health System, in the municipalities of the state of São Paulo. Rev Bras Epidemiol. 2019;22 :e190053. doi: 10.1590/1980-549720190053. PubMed PMID:31826109 .
  10. Marco, FD, Pellegrino, GM, Papa, GFS. The need for a national perspective to improve COPD management. J Bras Pneumol. 2019;45 (6):e20190349. doi: 10.1590/1806-3713/e20190349. PubMed PMID:31826103 .
  11. Morais, LA, Cavalcante, SYIES, Conde, MB, Rabahi, MF. Evaluating the disease and treatment information provided to patients with chronic obstructive pulmonary disease at the time of discharge according to GOLD discharge guidelines. Einstein (Sao Paulo). 2019;18 :eAO4706. doi: 10.31744/einstein_journal/2020AO4706. PubMed PMID:31826076 .
  12. Jiao, Y, Li, Y, Ji, B, Cai, H, Liu, Y. Clinical Value of lncRNA LUCAT1 Expression in Liver Cancer and its Potential Pathways. J Gastrointestin Liver Dis. 2019;28 (4):439-447. doi: 10.15403/jgld-356. PubMed PMID:31826070 .
  13. Probst, M, Gogolka, A, Krüll, M, Noga, O. In search of clinically relevant parameters to monitor successful omalizumab therapy in allergic asthma. Allergol Select. 2018;2 (1):49-55. doi: 10.5414/ALX01377E. PubMed PMID:31826042 PubMed Central PMC6881860.
  14. Vundavilli, H, Datta, A, Sima, C, Hua, J, Lopes, R, Bittner, ML et al.. Using Chou's 5-steps rule to Model Feedback in Lung Cancer. IEEE J Biomed Health Inform. 2019; :. doi: 10.1109/JBHI.2019.2958042. PubMed PMID:31825884 .
  15. Stifter, SA, Bhattacharyya, N, Sawyer, AJ, Cootes, TA, Stambas, J, Doyle, SE et al.. Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo. Cell Rep. 2019;29 (11):3539-3550.e4. doi: 10.1016/j.celrep.2019.11.021. PubMed PMID:31825834 .
  16. Vijayaraj, P, Minasyan, A, Durra, A, Karumbayaram, S, Mehrabi, M, Aros, CJ et al.. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019;29 (11):3488-3505.e9. doi: 10.1016/j.celrep.2019.11.019. PubMed PMID:31825831 .
  17. Balaji Ragunathrao, VA, Anwar, M, Akhter, MZ, Chavez, A, Mao, Y, Natarajan, V et al.. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling. Cell Rep. 2019;29 (11):3472-3487.e4. doi: 10.1016/j.celrep.2019.11.036. PubMed PMID:31825830 .
  18. Hoj, JP, Mayro, B, Pendergast, AM. A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Cell Rep. 2019;29 (11):3421-3434.e8. doi: 10.1016/j.celrep.2019.11.018. PubMed PMID:31825826 .
  19. Shang, L, Wang, L, Shi, X, Wang, N, Zhao, L, Wang, J et al.. HMGB1 was negatively regulated by HSF1 and mediated the TLR4/MyD88/NF-κB signal pathway in asthma. Life Sci. 2019; :117120. doi: 10.1016/j.lfs.2019.117120. PubMed PMID:31825792 .
  20. Cho, JH, Lim, SH, An, HJ, Kim, KH, Park, KU, Kang, EJ et al.. Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09). J. Clin. Oncol. 2019; :JCO1900931. doi: 10.1200/JCO.19.00931. PubMed PMID:31825714 .
  21. Scorsetti, M, Comito, T, Franceschini, D, Franzese, C, Prete, MG, D'Alessio, A et al.. Is there an oligometastatic state in pancreatic cancer? Practical clinical considerations raise the question. Br J Radiol. 2019; :20190627. doi: 10.1259/bjr.20190627. PubMed PMID:31825664 .
  22. Venado, A, Witt, LJ, Kallianos, K, Wolters, PJ. Diaphragmatic Atrophy May Limit Progression of Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201905-0989IM. PubMed PMID:31825660 .
  23. Quaife, SL, Ruparel, M, Dickson, JL, Beeken, RJ, McEwen, A, Baldwin, DR et al.. Lung Screen Uptake Trial (LSUT): Randomised Controlled Trial Testing Targeted Invitation Materials. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201905-0946OC. PubMed PMID:31825647 .
  24. Wang, L, Bierbrier, R, Drucker, AM, Chan, AW. Noncutaneous and Cutaneous Cancer Risk in Patients With Atopic Dermatitis: A Systematic Review and Meta-analysis. JAMA Dermatol. 2019; :. doi: 10.1001/jamadermatol.2019.3786. PubMed PMID:31825457 .
  25. Shi, H, Xu, M, Zhu, J, Li, Y, He, Z, Zhang, Y et al.. Programmed co-delivery of platinum nanodrugs and gemcitabine by a clustered nanocarrier for precision chemotherapy for NSCLC tumors. J Mater Chem B. 2019; :. doi: 10.1039/c9tb02055a. PubMed PMID:31825452 .
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