Latest in Pulmonary News

Thirty-Day Hospital Readmission Metric Linked to Increased Mortality for HF and Pneumonia

Physicians are at increased pressure to reduce readmissions for certain chronic diseases. A recent study found that implementation of the 30-day readmission rules has been associated with increased 30-day post-discharge mortality for those hospitalized for heart failure and pneumonia.

Post-discharge deaths have increased by 0.25% for patients hospitalized with heart failure and by 0.40% for patients with pneumonia since the implementation of the 30-day readmission rules.
There are approximately 8 million hospitalizations during the study period. Such small increases may account for a large number of deaths.

The findings, published online in JAMA, come from a retrospective cohort study that compared mortality rates among 8.3 million Medicare beneficiaries hospitalized for these common conditions before and after implementation of the Hospital Readmissions Reduction Program (HRRP). This early data should lead physicians to exercise caution in discharging patients prematurely.

Source: Association of the Hospital Readmissions Reduction Program With Mortality Among Medicare Beneficiaries Hospitalized for Heart Failure, Acute Myocardial Infarction, and Pneumonia. JAMA. 2018;320(24):2542-2552. doi:10.1001/jama.2018.19232

Add Corticosteroids to Your Arsenal for the treatment of Inpatient Community-Acquired Pneumonia.

Corticosteroids were both beneficial and cost-effective for hospitalized adults with severe CAP. Hospitalized people with non-severe CAP may also benefit from corticosteroid therapy, but with no survival advantage

In 2015, results of two randomized trials showed that systemic corticosteroids were beneficial for some hospitalized patients with community-acquired pneumonia (CAP; NEJM JW Gen Med Mar 15 2015 and JAMA 2015; 313:677; NEJM JW Gen Med Mar 1 2015 and Lancet 2015; 385:1511). Now, two new meta-analyses — one by the Cochrane Library, and one by the Infectious Diseases Society of America (IDSA) — address whether CAP patients should receive systemic corticosteroids routinely.

These meta-analyses suggest that low-dose (≈40 mg), short-course (3–7 days) systemic corticosteroids should be strongly considered for hospitalized adults with severe CAP. These results do not apply to outpatients with CAP or to inpatients with hospital-acquired pneumonia or ventilator-associated pneumonia. Several ongoing randomized trials probably will clarify steroid use further for pneumonia indications.

Source:
The Cost-effectiveness of Corticosteroids for the treatment of Community-Acquired Pneumonia
Chest. 2018 Nov 15. pii: S0012-3692(18)32727-2. doi: 10.1016/j.chest.2018.11.001.
https://www.ncbi.nlm.nih.gov/pubmed/30448195?dopt=Abstract

Home oxygen therapy for COPD: Does it matter whether the patient is hypoxemic? Evidence vs Reality

Home oxygen therapy for COPD: Does it matter whether the patient is hypoxemic? Evidence vs Reality?

Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxemia who do not meet the criteria for LTOT has not been established. Scientific evidence for its benefits of LTOT dates back to the 1980s when two randomized controlled trials showed prolonged survival in COPD-patients undergoing LTOT for at least 15 hours/day. In contrast, the potential benefits of LTOT in non-COPD-patients has not been well researched and the recommendations for its application are primarily extrapolated from trials on COPD-patients.

Recent Cochrane analysis found that oxygen can relieve breathlessness when given during exercise to mildly hypoxaemic and non-hypoxaemic people with chronic obstructive pulmonary disease who would not otherwise qualify for home oxygen therapy. Findings show that COPD patients without severe hypoxemia undergoing oxygen therapy during exercise training over time do not achieve better exercise capacity or health-related quality of life compared with placebo.

However, LTOT has a beneficial effect on quality of life, dyspnea, and exercise capacity in patients with COPD and exertional hypoxemia.

Source:
Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006429.pub3/full

J Bras Pneumol. 2018 Sep-Oct;44(5):390-397. doi: 10.1590/S1806-37562017000000019.
Impact of adherence to long-term oxygen therapy on patients with COPD and exertional hypoxemia followed for one year.
https://www.ncbi.nlm.nih.gov/pubmed/30517340

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  1. Pyash, AS, Shoshi, HR, Biswas, MAAJ, Rahman, M, Haque, R, Petri, WA et al.. Incidence and Viral Etiology of Acute Respiratory Infections and Pneumonia among Children Under Two Years: A Birth Cohort Study in Dhaka, Bangladesh. Am J Trop Med Hyg. 2026;114 (2):237-246. doi: 10.4269/ajtmh.25-0466. PubMed PMID:41662758 .
  2. Denney, SF, Chantratita, N, Brett, PJ, Burtnick, MN. Understanding Gram-Negative Bacterial Infections in Thailand: An Analysis of Trends and Challenges. Am J Trop Med Hyg. 2026;114 (2):199-206. doi: 10.4269/ajtmh.25-0170. PubMed PMID:41662747 .
  3. Chuchu, V, Sayianka, S, Teresa, I, Inwani, I, Oyugi, J, Thumbi, SM et al.. Burden of Antibiotic Resistance in Hospitalized Children in Kenya: Associations with Mortality, Hospital Stay, and Treatment Costs. Am J Trop Med Hyg. 2026;114 (2):216-223. doi: 10.4269/ajtmh.25-0440. PubMed PMID:41662743 .
  4. Shwe, DD, Diala, UM, Kanhu, PU, Habila, H, Jeremiah, OE, Baba, FJ et al.. Neonatal Sepsis: Etiology, Antimicrobial Susceptibility, and Treatment Outcomes in a Tertiary Hospital in Jos, Nigeria. Am J Trop Med Hyg. 2026;114 (2):207-215. doi: 10.4269/ajtmh.24-0127. PubMed PMID:41662731 .
  5. Maliga, A, Ronca, SE, Manzanero, R, Melendez, R, Gunter, SM, Lino, A et al.. Infectious Causes of Acute Febrile Illness in Belize, 2020-2022. Am J Trop Med Hyg. 2026;114 (2):224-236. doi: 10.4269/ajtmh.25-0328. PubMed PMID:41662728 .
  6. Krzyżewska, A, Baranowska-Kuczko, M, Kozłowska, H. The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence. Br J Pharmacol. 2026; :. doi: 10.1111/bph.70347. PubMed PMID:41662725 .
  7. Guerrero-Pertiñez, G, Carbonell-Aranda, V, Pérez-Guerrero, G, Dawood-Hristova, JJ, Pérez-Aranda, A, Fernández-Martínez, S et al.. Resilience as a Mediator in a Web-Based Intervention (MINDxYOU) to Reduce Stress Among Health Care Professionals: Stepped-Wedge Cluster Randomized Trial. JMIR Ment Health. 2026;13 :e82905. doi: 10.2196/82905. PubMed PMID:41662682 .
  8. Danzeng, M, Anxin, L, Duoji, G, Pudroma, X. Antitumor Effect of 5-Aminolevulinic Acid Methyl Ester-Mediated Photodynamic Therapy on Local Skin Melanoma and Its Metastasized Tumor, in Relation with Antitumor Immunity. J Environ Pathol Toxicol Oncol. 2026;45 (1):43-54. doi: 10.1615/JEnvironPatholToxicolOncol.2025058961. PubMed PMID:41662678 .
  9. Higashi, RT, Etingen, B, Lee, J, Cole, S, Mansour, JC, Zhao, A et al.. Patient and Clinician Perspectives on Expanding Telehealth Use for Older Adults Across the Cancer Control Continuum: Mixed Methods Study. JMIR Cancer. 2026;12 :e73058. doi: 10.2196/73058. PubMed PMID:41662673 .
  10. Koliadi, A, Digkas, E, El-Naggar, AI, Ullenhag, G, Valachis, A. Influenza Vaccination Among Patients With Cancer Treated With Checkpoint Inhibitors: Association With Survival Outcomes and Immune-Related Adverse Events. JCO Oncol Pract. 2026; :OP2500660. doi: 10.1200/OP-25-00660. PubMed PMID:41662610 .
  11. Ching, CJY, Chan, SCL, Lee, TTL, Pui, HHH, Leung, BKH, Wong, MS et al.. Postpandemic Change in Demographic and Clinical Features of Patients With Omicron Who Were Hospitalized: Territory-Wide Retrospective Repeated Cross-Sectional Study in Hong Kong. JMIR Public Health Surveill. 2026;12 :e75635. doi: 10.2196/75635. PubMed PMID:41662574 .
  12. Wang, X, Jing, X, Guo, Z, Long, S, Sun, X, Appelberg, S et al.. Coviretinopathy: COVID-19-induced VEGF-dependent retinopathy. Proc Natl Acad Sci U S A. 2026;123 (7):e2516405123. doi: 10.1073/pnas.2516405123. PubMed PMID:41662529 .
  13. Choate, R, Holm, KE, Sandhaus, RA, Mannino, DM, Strange, C. Severe Obesity and Alpha-1 Antitrypsin Deficiency-Associated COPD: A Dual Burden on Health and Quality of Life. Chronic Obstr Pulm Dis. 2026; :. doi: 10.15326/jcopdf.2025.0672. PubMed PMID:41662511 .
  14. Press, VG, Katsikas, A, Swankoski, K, Boudreau, E, Thomas, E. Phone-Based Teach-To-Goal Inhaler Education Program for Medicare Advantage Beneficiaries With COPD. Chronic Obstr Pulm Dis. 2026; :. doi: 10.15326/jcopdf.2025.0667. PubMed PMID:41662505 .
  15. Thuy, PT, Thu, NT, Khan, NC. Silent Nights, Restless Lungs: Sleep Quality and Associated Factors Among COPD Patients in Vietnam - A Cross-Sectional Study. Chronic Obstr Pulm Dis. 2026; :. doi: 10.15326/jcopdf.2025.0664. PubMed PMID:41662503 .
  16. Youm, S, Han, C, Yoo, H, Jang, SH, Dorr, BJ. "I Still Need Your Help": Online information seeking behavior of International Students in the United States on Reddit. PLoS One. 2026;21 (2):e0341314. doi: 10.1371/journal.pone.0341314. PubMed PMID:41662464 .
  17. Altun, B, Hazırolan, G, Gür, D. Ceftolozane-tazobactam and ceftazidime-avibactam efficacy against K. pneumoniae: first NDM-5 and OXA-232 report from Türkiye. J Infect Dev Ctries. 2026;20 (1):98-103. doi: 10.3855/jidc.21385. PubMed PMID:41662426 .
  18. Mayilsamy, M, Parthasarathy, R, Veeramanoharan, R, Rajaiah, P. Changing trends of vector-borne diseases after the COVID-19 pandemic in India. J Infect Dev Ctries. 2026;20 (1):37-42. doi: 10.3855/jidc.21565. PubMed PMID:41662423 .
  19. Li, FF, Li, JJ, Zhang, Y, Wu, ZY, Xu, YH. Analysis of the Type VI secretion system and microbiological characteristics of hypervirulent Klebsiella pneumoniae causing urinary tract infections. J Infect Dev Ctries. 2026;20 (1):70-78. doi: 10.3855/jidc.21628. PubMed PMID:41662422 .
  20. Etiz, P, Ekenoğlu Merdan, Y, Avci, P. Distribution and antibiotic resistance of Gram-negative bacteria from blood cultures before and during the COVID-19 pandemic. J Infect Dev Ctries. 2026;20 (1):29-36. doi: 10.3855/jidc.20702. PubMed PMID:41662421 .
  21. Dharmawan, A, Pusparini,. The role of syndromic testing in pneumonia diagnosis: a comparison with culture methods. J Infect Dev Ctries. 2026;20 (1):62-69. doi: 10.3855/jidc.21072. PubMed PMID:41662420 .
  22. Stanic, JD, Jovanovic, LD, Jankovic, RM, Arsenijevic, TJ, Nikitovic, MR. Unraveling the rarity: p16-positive and p53-positive locally advanced anal cancer in a person living with HIV. J Infect Dev Ctries. 2026;20 (1):138-144. doi: 10.3855/jidc.21737. PubMed PMID:41662419 .
  23. Zheng, J, Liu, L, Zou, J, Liang, C, Zhang, Y, Peng, H et al.. Patients with SARS-CoV-2 Omicron variant infection complicated with myocardial injury: a retrospective cohort study. J Infect Dev Ctries. 2026;20 (1):19-28. doi: 10.3855/jidc.21008. PubMed PMID:41662418 .
  24. Kucukates, E, Karatas, A, Alacam, S. Intensive care units-acquired urinary tract infections: a 5-year multicenter retrospective study in Istanbul. J Infect Dev Ctries. 2026;20 (1):52-61. doi: 10.3855/jidc.20690. PubMed PMID:41662417 .
  25. Araj, GF, Frangieh, JG, Sobh, GM, Ghandour, LA. Antimicrobial resistance evolution over time during pre-and post-COVID-19 periods at a major tertiary care center in Lebanon. J Infect Dev Ctries. 2026;20 (1):12-18. doi: 10.3855/jidc.22191. PubMed PMID:41662413 .
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